The Stem Cell Cannabinoid
“Many of us are cannabinoid deficient. A multitude of disorders and their symptoms come come from a deficiency… CBG, the stem molecule which quickly converts to CBD, THC and other cannabinoids. CBG might turn out to be the most medicinal of the lot .”
Cannabigerol (CBG) is a cannabinoid found in higher concentrations in Hemp as opposed to weed selectively bred for high psychoactive THC content. Most strains of medical and recreational cannabis have minor amounts CBG, somewhere between 0.1 and 1%. The literature is very sparse and CBG is seldom quantified in industrial Hemp strains but average values appear to range from 0.2 to 2%. It may be possible to interrupt the enzyme activity which converts CBG into THC especially. Strains higher in CBG (est. 2-3%) have recently appeared in Europe and these new varieties are expected to appear on the market in the next year or so.
Cannabigerol (CBG) is not psychoactive and is known to block the metabolic action, psychoactive effects of THC. CBG was shown to stimulate neurogenesis (brain cell growth). CBG also is antibacterial, anti-tumor, and helps with insomnia. Based on the known and implied applications for CBG,
All the major cannabinoids – THC, CBD, and CBC in marijuana are biosynthesized from cannabigerol (CBG) by the rapid action of enzymes. Early harvesting, therefore, doesn’t necessarily lead to especially high amounts of CBG. It may be possible to interrupt the enzymatic action to greatly elevate CBG concentrations. With that said, it is feasible to extract separate CBG from Hemp in useful quantity. This is sure that an elite cannabis based medicine supplier will take on some day in the near future.
“Like the other cannabinoids found in cannabis, CBG exhibits is exceptionally non-toxic as compared to most prescribed pharmaceutical preparations. Observable negative side effects are practically absent in therapeutic doses.”
CBG can modulate the fight or flight response. In technical lingo, CNG has a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist. It also binds to the CB2 receptor, but it’s action is not well understood as yet (2016).
Potential modulation of the α2-adrenergic receptor by CBG implies the following potential action;
- Control fight and flight (stress, anxiety, anger, energy) Suppression of release of norepinephrine (noradrenaline)
- Stimulates High blood pressure dropping to low.
- Constriction of certain arteries, heart (coronary artery)
- Constriction of some vascular smooth muscle, veins
- Decrease motility of smooth muscle in gthe astrointestinal tract
- Inhibition of lipolysis, the breakdown of complex fats (lipids) into fatty acids
- Facilitates cognition, activity in the prefrontal cortex (PFC; working memory, attention, executive functioning, etc.)
- Sedative efffects
- Analgesia effects
CBG has been shown to :
- Relieves pain.
- Slow bacterial growth especially in certain species
- Reduces seizures and convulsions.
- Reduces inflammation systemically
- Induce sleep.
- Inhibits cancer cell growth
- Promotes bone growth.
- Stimulate growth of new brain cells
Conditions under Study:
Evidence that cannabigerol can activate alpha(2)-adrenoceptors, bind to cannabinoid CB(1) and CB(2) receptors and block CB(1) and 5-HT(1A) receptors
Different plant-derived and synthetic cannabinoids have shown to be neuroprotective in experimental models of Huntington’s disease We studied the effects of cannabigerol (CBG), CBG was extremely active as na europrotectant. improving motor deficits and preserving striatal neurons. CBG reduced proinflammatory markers and improved the levels of antioxidant defenses. In conclusion, our results open new research avenues for the use of CBG, alone or in combination with other phytocannabinoids or therapies, for the treatment of neurodegenerative diseases such as HD.
We investigated the effect of cannabigerol (CBG), a non-psychotropic Cannabis-derived cannabinoid, in a murine model of colitis. In conclusion (it worked), CBG attenuated murine colitis, reduced nitric oxide production in macrophages (effect being modulated by the CB2 receptor) and reduced ROS formation in intestinal epithelial cells. CBG could be considered for clinical experimentation in IBD patients.
This investigation has provided the first evidence that cannabigerol can activate α2-adrenoceptors, bind to cannabinoid CB1 and CB2 receptors and block CB1 and 5-HT1A receptors. It will now be important to investigate why cannabigerol produced signs of agonism more potently in the [35S]GTPγS binding assay than in the vas deferens and also whether it can inhibit noradrenaline uptake in this isolated tissue and in the brain.
Here, we demonstrate for the first time that CBG elicits hyperphagia, by reducing latency to feed and increasing meal frequency, without producing negative neuromotor side effects. Investigation of the therapeutic potential of CBG for conditions such as cachexia and other disorders of eating and body weight regulation is thus warranted.
Mikey Kush 25-30% THC 3% Cannabigerol
Micky Kush is a 75% sativa cross between Sweet Irish Kush and Jack The Ripper. … with earthy, kush flavor with lemon undertones, and deliver energetic, focused effects…. super high THC and CBG especially popular for treating nausea, pain, and depression…..medium height with a moderate to heavy yield, flowers in 7 and 8 weeks.
Cannabinoid profiling informs patients about the concentration of active cannabinoids in their medicine….while THC is the most well-known cannabinoid, it is only responsible for a fraction of cannabis’ medicinal benefits. therefore it is wise to test for CBD, CBDA, CBN, CBG, CBC and THCA….
Bleu Berries (White Label) and Eldorado (Sativa Seedbank) show 1.8% and 1.5% CBG from tests. ….. some Sativa Landraces may have higher CBG but no test results I can find….
While it may take some time, have confidence that CBG-only strains will soon be as available as CBD varieties….
MMJ DOCTOR: If you find a strain that is high in CBG, you’re going to need a doctor’s recommendation to buy your medication from a licensed medical marijuana dispensary, cannabis clinic, marijuana grow cooperative or delivery service. We specialize in same day 420 evaluations 100% confidential… We also provide Cannabis ID Cards and grower’s permits valid in the state of California. Click here to schedule your online appointment with California licensed Medical Marijuana doctors .